Synthesis and Antimicrobial Evaluation of some New Pyrazole, Pyrazoline and Chromeno[3,4-c]pyrazole Derivatives
نویسندگان
چکیده
Alguns novos derivados de pirazol-5-carbonitrila 8,9 e pirazol-5-carboxamida 13 foram sintetizados pela reação de cicloadição de nitriliminas 3,4 a α-cianocinamonitrilas 5a-f e α-cianocinamamida 12a,b, respectivamente. Por outro lado, a adição de 3,4 a α-cianocinamato de etila 14a-f leva à produção de derivados de 2-pyrazoline-5-carboxilato de etila, 15, 16. Também, a cicloadição de 3,4 à 3-cianocumarina 19a ou à 3-fenilsulfonilcumarina 19b ou à 3-bromocumarina 19c leva à produção de derivados do cromeno[3,4-c]pirazol-4(3H)-ona, 20. A cicloadição de 3,4 à 3-acetilcumarina, 22 e 3-benzoilcumarina, 23, produz o correspondente diidrocromeno[3,4-c] pirazol-4(3H)-ona, 24 e 25, respectivamente. A oxidação de 24 e 25 produz 20. A maioria dos compostos preparados mostrou boa a moderada atividade antibacteriana e antifúngica.
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